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Related Experiment Videos

Ganglionic herpes simplex and systemic acyclovir.

D Pavan-Langston, N H Park, M Hettinger

    Archives of Ophthalmology (Chicago, Ill. : 1960)
    |August 1, 1981
    PubMed
    Summary
    This summary is machine-generated.

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    Acyclovir effectively treats ganglionic herpes simplex virus (HSV) in mice when initiated early post-infection, even after treatment cessation. However, its suppressive effect on established latent HSV is transient, with viral titers re-emerging post-therapy.

    Area of Science:

    • Virology
    • Pharmacology
    • Neuroscience

    Background:

    • Herpes simplex virus (HSV) establishes latent infections in ganglia.
    • Acyclovir is a primary antiviral agent used for HSV infections.
    • Understanding acyclovir's efficacy against ganglionic HSV is crucial for treatment strategies.

    Purpose of the Study:

    • To investigate the therapeutic and systemic effects of acyclovir on ganglionic HSV in a mouse model.
    • To determine the impact of treatment duration and timing of ganglia removal on acyclovir's efficacy.
    • To assess acyclovir's effect on established latent ganglionic HSV.

    Main Methods:

    • Mice infected with HSV were treated with acyclovir at varying times post-infection.
    • Ganglia were harvested and cultured at different intervals after treatment cessation.

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  • Viral presence in ganglia was assessed via co-cultivation.

    • Main Results:

    • Early acyclovir treatment (3 hours post-infection) showed significant therapeutic effects, persisting even 17 days after treatment ended.
    • Late acyclovir treatment (24 hours post-infection) had no significant effect.
    • Treatment of established latent HSV for 15 days resulted in a transient therapeutic effect, lost by 10-21 days post-therapy.

    Conclusions:

    • Acyclovir demonstrates significant therapeutic potential against early-stage ganglionic HSV infections.
    • The antiviral effect of acyclovir on established latent ganglionic HSV is temporary, with viral reservoirs re-establishing after drug withdrawal.
    • Treatment timing is critical for acyclovir's effectiveness in managing ganglionic HSV.