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[Iatrogenic menopause: a case report (author's transl)].

B Humbert

    La Semaine Des Hopitaux : Organe Fonde Par L'Association D'Enseignement Medical Des Hopitaux De Paris
    |June 8, 1981
    PubMed
    Summary

    Chemotherapy-induced menopause can cause hot flushes. Veralipride effectively treated these symptoms in a Hodgkin

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    Area of Science:

    • Oncology
    • Endocrinology
    • Pharmacology

    Background:

    • Chemotherapy, specifically MOPP (mechlorethamine, oncovin, procarbazine, and prednisone), can induce artificial menopause.
    • Artificial menopause is associated with hormonal changes, including elevated Follicle-Stimulating Hormone (FSH) and diminished 17 beta-estradiol levels.

    Observation:

    • A 25-year-old woman undergoing chemotherapy for Hodgkin's disease experienced severe hot flushes due to induced artificial menopause.
    • Hormonal evaluation revealed significantly elevated plasma FSH and markedly reduced 17 beta-estradiol levels.

    Findings:

    • Treatment with Veralipride (100 mg daily for 20 days) resulted in the complete resolution of hot flushes.
    • No recurrence of hot flushes was observed during a 4-month follow-up period after treatment cessation.
    • Veralipride demonstrated excellent tolerance in the patient.

    Implications:

    • Veralipride is a potential therapeutic option for managing hot flushes associated with chemotherapy-induced menopause.
    • These findings align with existing literature on Veralipride's efficacy in treating menopausal symptoms.
    • Further research may explore Veralipride's role in improving quality of life for cancer survivors experiencing menopausal side effects.

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