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Goat lymphosarcoma from bovine leukemia virus
Journal of the National Cancer Institute
|September 1, 1981
Summary
A goat developed lymphosarcoma 8 years after inoculation with bovine leukemia virus (BLV). Molecular and serologic studies confirmed BLV as the cause of the tumor in this animal.
Area of Science:
- Veterinary Pathology
- Oncology
- Virology
Background:
- Bovine leukemia virus (BLV) is an oncogenic retrovirus primarily affecting cattle.
- Lymphosarcoma is a common malignancy associated with BLV infection in adult cattle.
Purpose of the Study:
- To investigate the potential of BLV to induce lymphosarcoma in a caprine model.
- To characterize the pathological and molecular evidence of BLV-induced neoplasia in a goat.
Main Methods:
- Inoculation of a goat with BLV-infected sheep lymphocytes.
- Long-term clinical monitoring and necropsy of the experimental animal.
- Histopathological examination of tumor tissues.
- Viral culture and detection of BLV antibodies.
- Molecular hybridization to identify BLV provirus in tumor DNA.
Main Results:
- The goat developed lymphosarcoma affecting multiple organs 8 years post-inoculation.
- BLV was cultured from lymphocytes early in the infection, and antibodies persisted.
- BLV provirus was detected in tumor DNA from lymph nodes, mesentery, omentum, body wall, and retrobulbar tissues.
- Tumor histology was consistent with BLV-associated lymphosarcoma in cattle.
Conclusions:
- This study provides strong evidence that BLV can induce lymphosarcoma in goats.
- The findings support the use of goats as a model for studying BLV-associated lymphomagenesis.
- BLV-induced lymphosarcoma in goats shares pathological and molecular similarities with the bovine disease.