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[Clinical experience with cefotiam (author's transl)]
Insights
Cefotiam (CTM) demonstrated good to fair clinical efficacy in treating pediatric infections like acute tonsillitis and bronchopneumonia. Bacterial eradication was achieved in most cases with minimal side effects.
Area of Science:
- Pediatric Infectious Diseases
- Clinical Pharmacology
- Bacteriology
Background:
- Cefotiam (CTM) is a cephalosporin antibiotic.
- Assessing CTM's clinical utility in pediatric patients is important for treatment guidelines.
Observation:
- Six pediatric patients (five 1-year-olds, one 7-year-old) with acute tonsillitis, phlegmon, bronchopneumonia, and cervical abscess were treated with CTM.
- CTM was administered intravenously at 50-115 mg/kg/day in divided doses for 4-8 days.
- Causative pathogens included Staphylococcus aureus, Haemophilus parainfluenzae, and Klebsiella pneumoniae.
Findings:
- Bacterial eradication was successful in 5 out of 6 cases, with S. aureus being the only persistent pathogen in one instance.
- Overall clinical response was good in 4 patients and fair in 2 patients.
- Transient elevations in liver enzymes (GOT, GPT) were noted in one patient; no other adverse effects were reported.
Implications:
- Cefotiam exhibits promising clinical effectiveness and a favorable safety profile for treating various pediatric bacterial infections.
- Further investigation into CTM's efficacy against resistant strains like S. aureus may be warranted.
Abstract:
Cefotiam (CTM) were clinically applied to 6 cases and the following results were obtained: 1. The patients were aged 1 year in 5 cases and 7 years in 1 case. They comprised three cases of acute tonsillitis and 1 case each of phlegmon, bronchopneumonia and cervical abscess. CTM was administered in a daily dose of 50-115 mg/kg t.i.d. by an 1-hour intravenous drip infusion for 4 to 8 days. 2. The causative bacteria were S. aureus in 3 cases and H. parainfluenzae, K. pneumoniae and unknown pathogen in each 1 case. The organisms were eradicated in all cases except for only 1 case of S. aureus. 3. Overall responses were good in 4 cases and fair in 2 cases. 4. As for the abnormal laboratory findings, slight increase of GOT and GPT was observed in 1 case. Any other side effects were not observed.