Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

97Ru-DMSA for delayed renal imaging.

Z H Oster, P Som, M C Gil

    Radiology
    |October 1, 1981
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Uterine proteomic and cytokine profiling show that Streptococcus equi subsp. zooepidemicus induces immune-metabolic dysregulation and may predispose mares to endometrosis.

    Animal reproduction science·2025
    Same author

    Bacterial endometritis-induced changes in the endometrial proteome in mares: Potential uterine biomarker for bacterial endometritis.

    Theriogenology·2024
    Same author

    Evaluation of testicular echotexture with Ecotext as a diagnostic method of testicular dysfunction in stallions.

    Theriogenology·2022
    Same author

    How does the microbial load affect the quality of equine cool-stored semen?

    Theriogenology·2018
    Same author

    A simple flow cytometry protocol to determine simultaneously live, dead and apoptotic stallion spermatozoa in fresh and frozen thawed samples.

    Animal reproduction science·2017
    Same author

    Stallion spermatozoa surviving freezing and thawing experience membrane depolarization and increased intracellular Na<sup></sup>.

    Andrology·2017
    Same journal

    Erratum for: Prediction of Lobar Emphysema Progression with a CT-Based Foundational Model.

    Radiology·2026
    Same journal

    Erratum for: Associations of MRI-derived Paraspinal IMAT and LMM with Cardiometabolic Risk Factors: Results from a German Cohort.

    Radiology·2026
    Same journal

    Erratum for: Blue Rubber Bleb Nevus Syndrome.

    Radiology·2026
    Same journal

    Redefining the Clinical Role of MRI in Endometrial Cancer Staging.

    Radiology·2026
    Same journal

    To Ablate or Not to Ablate: The Colorectal Liver Metastasis Question.

    Radiology·2026
    Same journal

    The Limits of Radiologic Categorization in Pulmonary Nonsolid Nodules.

    Radiology·2026
    See all related articles

    The study found that 97Ru-Dimercaptosuccinic acid (DMSA) with tin (Sn+2) improved renal cortex imaging in dogs with kidney issues. This tin-containing agent shows potential for delayed renal scintigraphy when kidney function is compromised.

    Area of Science:

    • Nuclear medicine
    • Radiopharmaceutical chemistry
    • Renal imaging

    Background:

    • Dimercaptosuccinic acid (DMSA) is a common renal imaging agent.
    • Improving the visualization of the renal cortex, especially in compromised kidneys, is clinically significant.

    Purpose of the Study:

    • To evaluate the efficacy of 97Ru-labeled DMSA for renal imaging.
    • To compare the cortical deposition of tin-containing versus tin-free 97Ru-DMSA preparations.
    • To assess the utility of 97Ru-(Sn+2)-DMSA for delayed scintigraphy in renal insufficiency.

    Main Methods:

    • Labeling of DMSA with 97Ru, with and without the addition of SnCl2·2H2O.
    • Administration of the radiolabeled DMSA preparations to normal dogs with induced renal insufficiency.
    • Assessment of renal cortical deposition and visualization at various time points post-injection (4-48 hours).

    Related Experiment Videos

    Main Results:

    • The tin-containing preparation (97Ru-(Sn+2)-DMSA) demonstrated higher cortical deposition of 97Ru-DMSA compared to the tin-free preparation.
    • Excellent visualization of the renal cortex was achieved between 4 and 48 hours post-injection in the animal model.
    • The 97Ru-(Sn+2)-DMSA agent provided clear imaging even in the presence of renal decompensation.

    Conclusions:

    • 97Ru-(Sn+2)-DMSA is a promising radiopharmaceutical for renal imaging.
    • The tin-containing formulation enhances cortical uptake and visualization.
    • This agent is potentially valuable for delayed renal scintigraphy in patients with kidney insufficiency or decompensation.