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[Cytoplasmic membrane damage and thromboplastinemia in hypercholesterolemia]
Biulleten' Eksperimental'Noi Biologii I Meditsiny
|August 1, 1981
Summary
Elevated levels of 5'-nucleotidase activity in blood plasma indicate injury to vascular external cell membranes during hypercholesterolemia. This finding may serve as a risk factor for thrombus formation.
Area of Science:
- Vascular biology
- Biochemistry
- Cardiovascular research
Background:
- Alimentary hypercholesterolemia can lead to vascular wall injury.
- External cell membranes of the vascular wall may appear in blood flow during disease development.
Purpose of the Study:
- To investigate the injury of external cell membranes of the vascular wall in rabbits with alimentary hypercholesterolemia.
- To identify a marker for vascular cell membrane injury.
Main Methods:
- Experiments were conducted on 67 rabbits.
- The appearance of external cell membranes in blood plasma was monitored.
- 5'-nucleotidase activity was used as a specific marker for cell membrane injury.
Main Results:
- A significant increase in 5'-nucleotidase activity was observed in blood plasma at the peak of hypercholesterolemia.
- This increase indicates injury to the external cell membranes of the vascular wall.
Conclusions:
- Increased 5'-nucleotidase activity is an objective criterion for vascular external cell membrane injury.
- This injury may be a risk factor for thrombus formation in hypercholesterolemia.