[Effect of peritol on the activity of the hypothalamo-hypophyseo-adrenal system]

A study was made of the activity of the hypothalamo-hypophyseo-adrenal system under the effect of peritol (ciprohepatadin), an antagonist of serotonin receptors. Experiments were carried ot on male rats in which the blood content of corticosterone, aldosterone and ACTH was determined 3, 6 hours and 14, 20 and 30 days after peritol administration (twice a day). Pronounced inhibitory effect on the hypothalamo-hypophyseo-adrenal system was found to be attainable on a more frequent exposure (every 3 hours) to peritol with a purpose of maintaining the optimal drug concentration in various body tissues. The latter circumstance gives rise to peritol effect which is realized through both the central mechanisms (ACTH content) and as a result of direct action on steroid output.