[Timolol response in denervational syndromes (author's transl)].

Area of Science:

• Ophthalmology
• Pharmacology

Context:

• Pupillotony (Argyll Robertson) and Fuchs' heterochromic cyclitis are ocular conditions affecting intraocular pressure (IOP).
• Timolol maleate is a common topical medication used to manage IOP.

Purpose:

• To investigate the efficacy of timolol maleate in eyes with pupillotony and Fuchs' heterochromic cyclitis.
• To explore the physiological mechanisms underlying timolol's IOP-lowering effect.

Summary:

• The IOP-lowering effect of timolol maleate was significantly reduced in eyes with pupillotony compared to normal controls.
• In Fuchs' heterochromic cyclitis, timolol's effect on IOP was comparable to that in control eyes.
• Infrared thermography revealed a temperature drop preceding the maximal IOP reduction, suggesting a link to blood flow.

Impact:

• These findings indicate that the IOP-lowering action of timolol maleate is dependent on parasympathetic innervation.
• The study suggests that timolol may decrease blood flow within the ciliary body, contributing to its therapeutic effect.