[Timolol response in denervational syndromes (author's transl)]

In eyes with pupillotony (Argyll Robertson) the effect of locally applied timolol maleate (0.5%) on intraocular pressure is considerably less pronounced than in normal control eyes. In Fuchs' heterochromic cyclitis the timolol response is the same as in controls. Infrared thermography of the anterior segment of the eye showed that the maximum drop in IOP was preceded by a fall in temperature. These findings suggest that the IOP-lowering effect of timolol depends on parasympathetic innervation and that timolol decreases the blood flow in the ciliary body.