Changes in serum immunoglobulin concentrations in patients with multiple sclerosis during the treatment with ACTH

Changes in serum immunoglobulin (IgA, IgG, IgM) concentrations were studied in 31 patients with multiple sclerosis (MS) according to the clinical form of the disease, its duration and treatment with ACTH. The serum IgG concentration was increased on the onset of the disease, while it was significantly decreased in MS patients treated with ACTH for the first time. There was no significant relationship of serum immunoglobulin concentrations and the number of courses of treatment with ACTH or duration of MS.