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Is eosinophil chemotactic factor identical with leukotriene B?
International Archives of Allergy and Applied Immunology
|January 1, 1982
Summary
Eosinophil chemotactic factor (ECF) is similar to leukotriene B, derived from arachidonic acid. However, differences in ECF activity suggest it may not be identical to leukotriene B.
Area of Science:
- Biochemistry
- Immunology
Background:
- Eosinophil chemotactic factor (ECF) is a non-peptide substance that attracts eosinophils and neutrophils.
- ECF shares similarities with 5,12-di-HETE (leukotriene B) in its derivation from arachidonic acid, origin cells, physicochemical properties, and biological activity.
Purpose of the Study:
- To investigate the relationship between Eosinophil chemotactic factor (ECF) and leukotriene B.
- To determine if ECF can be definitively identified as leukotriene B.
Main Methods:
- Comparison of physicochemical characteristics and biological activity of ECF and leukotriene B.
- Analysis of ECF generation from different leukocyte types.
Main Results:
- ECF and leukotriene B share common origins from arachidonic acid and similar properties.
- Variations in ECF activity across different leukocytes indicate potential differences from leukotriene B.
Conclusions:
- ECF is closely related to, but not definitively identical to, leukotriene B.
- Further research is needed to identify potential isomers or unknown molecules contributing to ECF activity.