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A simple computer program for calculating, modifying and drawing circular restriction maps.

D M Lilley

    Nucleic Acids Research
    |January 11, 1982
    PubMed
    Summary
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    This study introduces a new HPL program for creating circular restriction maps from DNA cleavage data. The tool aids in analyzing DNA patterns, particularly for recombinant DNA molecules.

    Area of Science:

    • Molecular Biology
    • Bioinformatics

    Background:

    • Restriction mapping is crucial for analyzing DNA.
    • Interpreting restriction patterns, especially for recombinant DNA, can be complex.

    Purpose of the Study:

    • To describe a novel HPL program for constructing and visualizing circular restriction maps.
    • To provide a tool for simplifying the analysis of restriction patterns.

    Main Methods:

    • The study details an HPL program that takes cleavage site data as input.
    • The program can incorporate deletion or insertion data.
    • It generates visual representations of circular restriction maps.

    Main Results:

    • The HPL program successfully constructs circular restriction maps.

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  • The program visualizes the maps based on provided DNA cleavage data.
  • It handles optional deletion and insertion data.

    • Conclusions:

    • The developed HPL program is a valuable tool for molecular biology.
    • It streamlines the routine interpretation of restriction patterns.
    • Facilitates the analysis of recombinant DNA molecules.