Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Cervical lymph node metastases from an unknown primary tumour.

P Pacini, P Olmi, E Cellai

Acta Radiologica. Oncology

|January 1, 1981

Summary

Radiation therapy was used for 49 patients with cervical lymph node metastases from unknown primary tumors. The primary tumor was later identified in 7 cases, with survival rates at 2 and 5 years being 39% and 32%.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Interobserver variability of clinical target volume delineation in soft-tissue sarcomas.

Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique·2014

Same author

Unconjugated bisphenol A cord blood levels in boys with descended or undescended testes.

Human reproduction (Oxford, England)·2012

Same author

Tumor stage, human papillomavirus and smoking status affect the survival of patients with oropharyngeal cancer: an Italian validation study.

Annals of oncology : official journal of the European Society for Medical Oncology·2011

Same author

A benchmark study on 883 nasopharyngeal cancer patients treated in two Italian centres from 1977 to 2000. Part I: Evolving technical choices and survival.

La Radiologia medica·2011

Same author

Cancer reoccurrence in the conserved breast - diagnostic features in a consecutive series of 102 cases.

International journal of oncology·2011

Same author

Docetaxel, cisplatin and 5-fluorouracil-based induction chemotherapy followed by intensity-modulated radiotherapy concurrent with cisplatin in locally advanced EBV-related nasopharyngeal cancer.

Annals of oncology : official journal of the European Society for Medical Oncology·2011

Area of Science:

Oncology
Head and Neck Surgery

Background:

Cervical lymph node metastases from an unknown primary tumor (CUP) represent a significant clinical challenge.
Accurate diagnosis and effective treatment strategies are crucial for improving patient outcomes.

Purpose of the Study:

To review outcomes of patients treated with radiation therapy for cervical lymph node metastases of unknown primary origin.
To identify factors influencing survival in this patient cohort.

Main Methods:

Retrospective review of 49 patients diagnosed with cervical lymph node metastases from an unknown primary tumor.
All patients received radiation therapy as the primary treatment modality.
Analysis of survival rates and correlation with clinical and pathological factors.

Main Results:

The primary tumor was detected in 7 cases between 4 and 53 months post-treatment.
Crude survival rates at 2 and 5 years were 39% and 32%, respectively.
Survival was significantly correlated with patient sex, microscopic tumor appearance, disease stage, and extent of nodal involvement.

Conclusions:

Radiation therapy can achieve long-term survival in a subset of patients with cervical lymph node metastases from an unknown primary.
Prognostic factors such as sex, histology, stage, and nodal extent are critical for predicting outcomes.
Further research is warranted to optimize treatment strategies for unknown primary head and neck cancers.

Related Experiment Videos