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Adenovirus enteritis in pigs.

W Coussement, R Ducatelle, G Charlier

    American Journal of Veterinary Research
    |November 1, 1981
    PubMed
    Summary
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    Adenovirus strain 6618 caused diarrhea and intestinal lesions in pigs. Intranuclear inclusion bodies containing adenovirus particles were observed in the jejunum and ileum, confirming adenovirus enteritis.

    Area of Science:

    • Veterinary Pathology
    • Virology
    • Animal Science

    Background:

    • Porcine adenovirus infections can cause significant enteric disease in young pigs.
    • Understanding the pathogenesis of adenovirus enteritis is crucial for disease control.

    Purpose of the Study:

    • To characterize the pathological findings and viral presence in pigs experimentally infected with adenovirus strain 6618.
    • To investigate adenovirus enteritis using histopathology, electron microscopy, and immunoperoxidase staining.

    Main Methods:

    • Experimental inoculation of hysterectomy-produced, colostrum-deprived pigs with adenovirus strain 6618.
    • Histopathological examination of intestinal tissues for inclusion bodies.
    • Electron microscopy to visualize adenovirus particles within inclusion bodies.

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  • Immunoperoxidase staining to identify infected cells.
  • Negative staining of intestinal contents for viral detection.

    • Main Results:

    • Inoculated pigs developed diarrhea within 3-4 days post-infection.
    • Intranuclear inclusion bodies were identified in the short villi of the jejunum and ileum.
    • Electron microscopy confirmed the presence of adenovirus particles within these inclusion bodies.
    • Adenovirus particles were detected in intestinal contents and immunoperoxidase-positive cells were found in the affected villi.

    Conclusions:

    • Adenovirus strain 6618 experimentally induces enteritis in pigs.
    • The observed histopathological and ultrastructural findings are characteristic of porcine adenovirus enteritis.
    • This study confirms the utility of various diagnostic techniques for identifying adenovirus in porcine intestinal infections.