Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Aqueous ion channels.

D T Edmonds

    Biochemical Society Symposium
    |January 1, 1981
    PubMed
    Summary
    This summary is machine-generated.

    This study presents models for ion channels using ordered water cores, comparing calculated properties with real ion channel behavior. It highlights challenges in ion translocation across lipid membranes due to electrostatic energy limitations.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    The behaviour of ions in narrow water-filled pores.

    Bioscience reports·1999
    Same author

    A novel explanation for fluctuations of ion current through narrow pores.

    FASEB journal : official publication of the Federation of American Societies for Experimental Biology·1997
    Same author

    A sensitive optically detected magnetic compass for animals.

    Proceedings. Biological sciences·1996
    Same author

    Linear electric traction as an alternative model of the actin/myosin motor.

    Journal of theoretical biology·1996
    Same author

    Rapid switching of ion current in narrow pores: implications for biological ion channels.

    Proceedings. Biological sciences·1993
    Same author

    Correlated ion flux through parallel pores: application to channel subconductance states.

    The Journal of membrane biology·1993
    Same journal

    The cell biology of inositol lipids and phosphates. Proceedings of the 2006 Biochemical Society Annual Symposium. Birmingham, United Kingdom. March 29-30, 2006.

    Biochemical Society symposium·2007
    Same journal

    Trafficking of phosphatidylinositol by phosphatidylinositol transfer proteins.

    Biochemical Society symposium·2007
    Same journal

    Regulation of phospholipase D activity, membrane targeting and intracellular trafficking by phosphoinositides.

    Biochemical Society symposium·2007
    Same journal

    Evolution of the diverse biological roles of inositols.

    Biochemical Society symposium·2007
    Same journal

    Understanding the biological significance of diphosphoinositol polyphosphates ('inositol pyrophosphates').

    Biochemical Society symposium·2007
    Same journal

    Multiple functions of inositolphosphorylceramides in the formation and intracellular transport of glycosylphosphatidylinositol-anchored proteins in yeast.

    Biochemical Society symposium·2007
    See all related articles

    Area of Science:

    • Biophysics
    • Membrane Biophysics
    • Computational Biophysics

    Background:

    • Ion channels are crucial for cellular function, facilitating ion transport across lipid membranes.
    • Understanding the physical and chemical principles governing ion channel mechanisms is a fundamental challenge in biophysics.

    Purpose of the Study:

    • To describe theoretical models of ion channels featuring a central core of ordered water.
    • To compare the calculated characteristics of these water-core ion channel models with experimental data from real ion channels.

    Main Methods:

    • Descriptive modeling approach, referencing previous detailed calculations.
    • Introduction of electrostatic self-energy concepts to frame ion translocation challenges.
    • Discussion of environmental constraints for ion movement across lipid bilayers.

    Related Experiment Videos

    Main Results:

    • Models propose ordered water cores as a key structural element in ion channels.
    • Calculated channel properties are presented for comparison with experimental ion channel data.
    • The significant energetic barriers for ion translocation across the hydrophobic lipid bilayer are emphasized.

    Conclusions:

    • Ordered water core models offer a plausible mechanism for ion channel function.
    • Electrostatic self-energy presents a major biophysical constraint for ion permeation through lipid membranes.
    • Further refinement of models is needed to fully reconcile theoretical predictions with experimental ion channel observations.