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Transposable elements controlling genetic instabilities in mammals.

J B Whitney, M L Lamoreux

    The Journal of Heredity
    |January 1, 1982
    PubMed
    Summary
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    Gene action instabilities in mice may be explained by transposable DNA elements. Phenotypic evidence from mouse pigmentation loci supports this novel hypothesis.

    Area of Science:

    • Genetics
    • Molecular Biology
    • Developmental Biology

    Background:

    • Traditional hypotheses struggle to explain gene action instabilities observed in certain mouse alleles.
    • Modern research highlights the role of transposable DNA elements in various organisms.

    Purpose of the Study:

    • To propose and provide evidence for interpreting mouse gene action instabilities through the lens of transposable DNA elements.
    • To investigate specific mouse loci (a, c, H-2 Mi, p, pe, T, Va, W) exhibiting unusual gene action patterns.

    Main Methods:

    • Reviewing modern studies on transposable DNA elements (insertion sequences, transposons, controlling elements).
    • Examining phenotypic evidence in mice, particularly for loci affecting pigmentation (a, Mi, p, W).

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    Main Results:

    • Instabilities in mouse gene action at loci like a, Mi, p, and W can be better understood using models of transposable DNA elements.
    • Phenotypic data from these loci provide support for the proposed hypothesis.

    Conclusions:

    • Transposable DNA elements offer a more comprehensive framework for understanding complex gene action patterns in mice.
    • This hypothesis potentially reconciles previously unexplained genetic phenomena in mouse models.