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Modulation of the alternative complement pathways by beta 1 H globulin.

K Whaley, S Ruddy

The Journal of Experimental Medicine

|November 2, 1976

Summary

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Human plasma contains C3b inactivator accelerator (A-C3bINA), identified as beta 1 H. This protein potentiates C3b inactivation and regulates complement pathways by binding EAC43.

Area of Science:

Complement system immunology
Protein biochemistry

Background:

C3b inactivator accelerator (A-C3bINA) was isolated from human plasma.
The protein was identified as beta 1 H, a known contaminant in C3 preparations.

Purpose of the Study:

To characterize the physical and functional properties of beta 1 H.
To elucidate the role of beta 1 H in complement regulation.

Main Methods:

Antiserum production and immunodiffusion.
Analytical and sucrose density gradient ultracentrifugation.
SDS-PAGE and Sephadex G200 gel filtration.

Main Results:

Beta 1 H is a single polypeptide chain with significant carbohydrate content, exhibiting asymmetry.

Related Experiment Videos

It potentiates C3b inactivation by C3b inactivator and limits alternative pathway convertase formation.

Beta 1 H accelerates the decay of hemolytic sites on EAC43bB and EAC43bBP.

Conclusions:

Beta 1 H is a crucial regulator of the complement system, acting synergistically with C3b inactivator.
Its precise mechanisms of C3b binding and alternative pathway inhibition require further investigation.