[Cerebral gangliosides in dogs in experimental allergic encephalomyelitis]

Content of gangliosides was decreased in white substance of brain hemispheres and in spinal cord of dogs with typical symptoms of allergic encephalomyelitis. The decrease in content of less polar fractions was compensated by an increase in concentration of more polar gangliosides. After an intracisternal administration of the antibrain antibodies the content of gangliosides was also decreased in brain cortex and white substance of hemispheres. The data obtained suggest that the neurone membranes are impaired under the pathological conditions as well as that the antibrain antibodies are important for development of the structural impairments observed.