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Dose response experiments using the mouse tail model.

J Kirk, A M Perry, B R Cater

    Acta Radiologica. Oncology
    |January 1, 1982
    PubMed
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    Investigating radiation therapy effects in mice revealed that higher tissue temperatures, within a specific range, correlate with improved radiation response by altering oxygen levels. This finding has implications for combined radiation and hyperthermia treatments.

    Area of Science:

    • Radiation Oncology
    • Experimental Oncology
    • Biophysics

    Background:

    • Tissue temperature and local oxygenation are critical factors influencing the efficacy of radiation therapy.
    • Understanding these factors is essential for optimizing treatment protocols and improving patient outcomes.
    • Radiation-induced tail necrosis in BALB/c mice serves as a model to study radiation response.

    Purpose of the Study:

    • To investigate the impact of varying tissue temperatures on the radiation response in a murine model.
    • To explore the relationship between tissue temperature, local oxygenation, and the effectiveness of radiation therapy.
    • To develop a model explaining the observed temperature dependence of radiation response.

    Main Methods:

    • BALB/c mice were subjected to radiation-induced tail necrosis studies.

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  • Single doses of 250 kV roentgen-rays were administered across a temperature range of 32.5 to 37 degrees C.
  • Dose-response curves were generated to quantify the radiation effects at different temperatures.

    • Main Results:

    • A clear temperature dependence of the radiation response was observed.
    • The observed temperature effects were consistent with changes in local tissue oxygenation (hypoxic status).
    • A simple model was derived to explain the relationship between temperature, oxygenation, and radiation response.

    Conclusions:

    • Tissue temperature significantly modulates the response to radiation therapy in this model.
    • Changes in hypoxic status, influenced by temperature, are a key mechanism underlying this modulation.
    • The findings suggest practical applications for combining radiation therapy with hyperthermia in clinical settings.