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Gynandroblastoma: its ultrastructure.

A Chalvardjian, C Derzko

    Cancer
    |August 15, 1982
    PubMed
    Summary
    This summary is machine-generated.

    Gynandroblastoma, a rare ovarian tumor, caused masculinization in a patient. Surgical removal of the tumor resolved the symptoms, highlighting its role in sex-cord stromal tumors.

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    Area of Science:

    • Gynecologic Oncology
    • Endocrinology
    • Pathology

    Background:

    • Gynandroblastoma is a rare ovarian tumor exhibiting both female and male differentiation.
    • This tumor type is classified under sex-cord stromal tumors of the ovary.

    Observation:

    • A 24-year-old woman presented with symptoms of masculinization attributed to a gynandroblastoma.
    • Electron microscopy revealed distinct Call-Exner (CE) bodies in granulosa cell nests, differing from those in classic granulosa theca cell tumors.
    • Tumor tubules showed resemblance to rete ovarii, and Leydig cells with Reinke crystals were identified.

    Findings:

    • The patient's masculinization symptoms resolved post-tumor resection.
    • Distinct ultrastructural morphology of CE bodies (hyaline vs. spongiform type) was observed, related to basal lamina deposition.

    Related Experiment Videos

  • Ultrastructural analysis confirmed close resemblance between the various sex-cord components within the gynandroblastoma.

    • Implications:

    • This case underscores the potential for gynandroblastoma to induce clinical manifestations of virilization.
    • Understanding the ultrastructural variations in CE bodies aids in differentiating ovarian tumors.
    • The findings contribute to the classification and understanding of rare sex-cord stromal tumors.