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[Changes in the kinetic characteristics of reactions catalyzed by erythrocyte delta-aminolevulinate dehydratase in experimental lead poisoning in rats].

Voprosy meditsinskoi khimii·1986
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[Various regulatory properties of fructose-1,6-diphosphatase of the rat liver under normal conditions and in experimental autoimmune cardiomyopathy].

Voprosy meditsinskoi khimii·1986
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[Desensitization with acetylsalicylate and salicylate of fructose-1,6-diphosphatase from the rabbit liver and skeletal muscles to allosteric inhibition of AMP].

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[Complex type of kinetics of fructose-1,6-diphosphate from the rat and rabbit liver].

Biokhimiia (Moscow, Russia)·1985
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[Kinetic and allosteric properties of highly-purified, biosynthetic L-threonine dehydrogenase from brewer's yeast Saccharomyces carlsbergensis].

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[Comparative characteristics of the degree of health education among patients with tuberculosis and other diseases].

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[Regulatory enzymopathies].

Z S Kagan

    Voprosy Meditsinskoi Khimii
    |May 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

    Hereditary regulatory enzymopathies stem from gene mutations affecting enzyme allosteric regulation. Kinetic analysis aids in diagnosing these conditions, offering insights into treatment strategies.

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    Area of Science:

    • Biochemistry
    • Molecular Genetics
    • Enzymology

    Context:

    • Hereditary regulatory enzymopathies involve mutations in genes encoding regulatory enzymes.
    • These mutations impact the allosteric sites or conformational transition regions of enzymes.
    • Distinct clinical and molecular features differentiate regulatory from classical enzymopathies.

    Purpose:

    • To explore the molecular-genetic basis of hereditary regulatory enzymopathies.
    • To discuss the diagnostic utility of kinetic pattern analysis in regulatory enzymopathies.
    • To examine potential therapeutic interventions for regulatory enzymopathies.

    Summary:

    • Molecular-genetic mechanisms of hereditary regulatory enzymopathies involve mutations in structural genes affecting enzyme allosteric regulation.
    • Kinetic pattern estimation is crucial for diagnosing regulatory enzymopathies, exemplified by phosphofructokinase and phosphoribosyl pyrophosphate synthetase deficiencies.
    • Impaired allosteric regulation of L-threonine-L-serine dehydratase in mice serves as a model for studying regulatory enzymopathies and their treatment with drugs like acetylsalicylic acid.

    Impact:

    • Provides a framework for understanding the molecular basis of regulatory enzymopathies.
    • Highlights the importance of kinetic analysis in diagnosing complex enzyme disorders.
    • Offers insights into potential therapeutic targets and drug effects on allosteric enzyme function.