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Gynecomasty: histological aspects in a surgical material
Acta Pathologica, Microbiologica, Et Immunologica Scandinavica. Section A, Pathology
|May 1, 1982
Summary
Gynecomastia progresses from an active growth phase to a fibrous, inactive state. Lobule formation in male breast tissue is not solely linked to external hormone use.
Area of Science:
- Endocrinology
- Pathology
- Surgical Oncology
Background:
- Gynecomastia, characterized by male breast enlargement, requires histological evaluation.
- Understanding the distinct phases and potential cellular changes is crucial for diagnosis and management.
Purpose of the Study:
- To investigate the histological and clinical aspects of gynecomastia.
- To determine the relationship between lobule formation and exogenous hormone administration.
- To assess the significance of hyperplastic changes in gynecomastia cases.
Main Methods:
- Histological examination of breast tissue from 83 patients undergoing surgery for gynecomastia.
- Clinical correlation of histological findings.
Main Results:
- Gynecomastia exhibits a progression from an active proliferating phase to a fibrous, inactive phase.
- Lobule formation, similar to female breast tissue, was observed and not necessarily linked to exogenous hormone administration.
- Multicentric foci of atypical hyperplastic or early intraductal carcinoma-type epithelial hyperplasia were found in 6.5% of cases.
Conclusions:
- The study provides a detailed histological characterization of gynecomastia.
- Lobule formation in gynecomastia may occur independently of exogenous hormone exposure.
- The clinical significance of observed atypical hyperplastic changes in gynecomastia should not be overestimated, warranting careful interpretation.