Diminished lymphocyte responses to phytohemagglutinin in lung cancer

The PHA response of blood lymphocytes from lung cancer patients was found to be diminished in comparison to normal. Sera from these patients inhibited the blastogenic response of blood lymphocytes from normal subjects. Normal sera could restore to various levels the diminished PHA response of lymphocytes from lung cancer patients. The results suggest that the immunosuppression seen in lung cancer may be mediated by a factor (s) in the serum which might bound reversibly to a certain subpopulation of T-cells and permanently to another and or some other inhibitory mechanism does exist.