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Related Experiment Videos

Thyroid hormone-carbohydrate interaction at the hepatic nuclear level.

C N Mariash, J H Oppenheimer

    Federation Proceedings
    |August 1, 1982
    PubMed
    Summary

    Triiodothyronine (T3) and carbohydrate (CHO) synergistically induce liver enzymes. Glucose acts as a primary signal, multiplied by T3, with this effect diminishing in aging and certain disease states.

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    Molecular and cellular biology·2000

    Area of Science:

    • Metabolic regulation
    • Hormonal signaling
    • Molecular endocrinology

    Background:

    • Hepatic lipogenic enzymes are crucial for metabolism.
    • Thyroid hormones, like triiodothyronine (T3), play a role in metabolic control.
    • Carbohydrate availability influences metabolic enzyme activity.

    Purpose of the Study:

    • To investigate the synergistic interaction between T3 and carbohydrate (CHO) in inducing hepatic lipogenic enzymes.
    • To elucidate the role of glucose as a primary signal in enzyme induction.
    • To examine the impact of aging and metabolic conditions (starvation, diabetes) on this interaction.

    Main Methods:

    • In vivo studies in animal models.
    • In vitro studies using primary hepatocyte cultures.
    • Analysis of enzyme induction under varying T3 and CHO levels.
    • Assessment of gene expression patterns.

    Main Results:

    • A synergistic relationship exists between T3 and CHO in inducing hepatic lipogenic enzymes.
    • Glucose independently induces hepatic malate dehydrogenase (ME) in cultured hepatocytes.
    • T3 acts as a multiplier of the glucose-induced signal.
    • The response to both T3 and CHO is diminished in aging animals and inhibited in starvation and diabetes.

    Conclusions:

    • T3 likely functions at a molecular level by multiplying other nuclear signals, such as those generated by glucose.
    • Glucose is a primary inducer of hepatic ME, independent of T3.
    • The synergistic interaction between T3 and CHO is complex and influenced by physiological state and age.

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