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[Immune complexes and peripheral neuropathy: about two cases (author's transl)].

A Weber, F Barontini, M Colafranceschi

    Rivista Di Patologia Nervosa E Mentale
    |May 1, 1982
    PubMed
    Summary

    Immune complexes may cause progressive neuropathy in patients with chronic hepatitis or tuberculosis. Treatment targeting these complexes, like nephrectomy, improved symptoms and reduced immune complex levels.

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    International journal of clinical & laboratory research·1998

    Area of Science:

    • Neurology
    • Immunology
    • Pathology

    Background:

    • Investigating the pathogenesis of sensory-motor mononeuritis multiplex.
    • Examining potential immune-mediated mechanisms in peripheral neuropathies.

    Observation:

    • Two female patients presented with progressive distal sensory-motor mononeuritis multiplex.
    • Patient 1 had chronic active hepatitis; Patient 2 had localized tuberculous kidney infection.
    • Both patients exhibited elevated circulating immune complexes and complement system activation.

    Findings:

    • Nerve biopsy in Patient 1 revealed demyelination, vasculitis, and perivasculitis.
    • Patient 1's neuropathy progressed with persistent immune complexes.
    • Patient 2's neuropathy improved after nephrectomy, correlating with immune complex resolution.

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    Implications:

    • Suggests an immune complex-mediated pathway in these neuropathies.
    • Highlights the role of immune dysregulation in neurological disorders.
    • Supports potential therapeutic strategies targeting immune complexes in similar cases.