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Adenoviral pancreatitis in rhesus monkeys: current knowledge
Veterinary Pathology. Supplement
|September 1, 1982
Summary
Adenoviral pancreatitis was studied in rhesus monkeys. Findings suggest a gastrointestinal adenovirus infection can ascend to the pancreas, indicating a potential cause for pancreatitis in this species and possibly humans.
Area of Science:
- Veterinary Pathology
- Virology
- Gastroenterology
Background:
- Adenoviral infections can cause various diseases.
- Pancreatitis is a significant condition in nonhuman primates.
- The role of adenoviruses in pancreatitis is not well-established.
Purpose of the Study:
- To investigate the features and pathogenesis of adenoviral pancreatitis in rhesus monkeys.
- To determine the incidence and species susceptibility to adenoviral pancreatitis in nonhuman primates.
- To explore the potential link between adenovirus and pancreatitis in humans.
Main Methods:
- Immunofluorescence staining on pancreatic and gastrointestinal tissues from two rhesus monkey cases.
- Retrospective survey of over 3,000 pancreatic microslides from 1,002 nonhuman primates.
- Histopathological examination for adenoviral pancreatitis lesions.
Main Results:
- Adenovirus antigen detected in epithelial cells of pancreatic ducts, duodenum, and jejunum.
- Evidence suggests gastrointestinal adenovirus infection ascends to the pancreas via ducts.
- Adenoviral pancreatitis identified as a distinct entity in rhesus monkeys, with low incidence in other primates.
Conclusions:
- Adenoviral pancreatitis is a specific condition in rhesus monkeys that should be considered in differential diagnoses.
- Primary adenovirus infection of the GI tract may lead to pancreatitis.
- Findings suggest a potential viral etiology for some human pancreatitis cases.