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Inhibitory activity of cytosine arabinoside on Marek's disease virus
Folia Biologica
|January 1, 1982
Abstract:
The presence of ara-C in growth medium at concentrations of 10(-4) to 10(-7) M completely or partially suppressed the formation of plaques specific for MDV or HVT and decreased proportionally the growth of HPRS line 1 lymphoblastoid cells. Administration of ara-C to chickens immediately after infection with MDV (1 mg/chicken/day i.p. for 5 days) reduced the incidence of Marek's disease by 50%. Thus ara-C appears to be an inhibitor of Marek's disease.