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Computed tomographic study of hormone-secreting microadenomas
Radiology
|January 1, 1983
Summary
Computed tomography (CT) can identify pituitary microadenomas by showing a diminished enhancement and enlarged gland, especially for prolactin-secreting tumors. These findings are key for diagnosing hormone-secreting microadenomas.
Area of Science:
- Radiology
- Endocrinology
- Neurosurgery
Background:
- Pituitary microadenomas are small tumors that secrete hormones.
- Previous computed tomographic (CT) studies reported varied appearances of pituitary microadenomas.
- Accurate identification of microadenomas is crucial for effective patient management.
Purpose of the Study:
- To review computed tomographic (CT) findings in patients with verified hormone-secreting microadenomas.
- To determine the most reliable CT criteria for identifying pituitary microadenomas.
Main Methods:
- Retrospective review of CT scans from 33 patients with surgically and endocrinologically confirmed hormone-secreting microadenomas.
- Analysis of CT appearance, including density and gland size.
- Correlation of CT findings with tumor hormone secretion type.
Main Results:
- CT demonstrated diminished enhancement and typically an enlarged pituitary gland in prolactin-secreting adenomas.
- Hormone-secreting adenomas (HGH- or ACTH-secreting) were less consistently hypodense on CT.
- Hypodensity and pituitary enlargement were the most consistent indicators of microadenomas.
Conclusions:
- Pituitary gland hypodensity and enlargement on CT are the most useful criteria for identifying microadenomas.
- Technical factors can influence CT appearance and contribute to conflicting reports.
- CT is a valuable tool for the diagnosis of hormone-secreting pituitary microadenomas.