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The enteroviruses: recent advances.

H A Wenner

    The Yale Journal of Biology and Medicine
    |May 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

    Human enteroviruses, including new and old serotypes, are continually studied for their impact on diseases. Research tracks their effects on various age groups and links them to serious conditions like heart and pancreas damage.

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    Area of Science:

    • Virology
    • Infectious Diseases
    • Immunology

    Background:

    • Human enteroviruses are a diverse group of viruses with ongoing discoveries of new serotypes.
    • Understanding enterovirus epidemiology, including age-specific attack rates and clinical manifestations, is crucial.
    • Enteroviruses have been associated with significant morbidity and mortality, particularly in vulnerable populations.

    Purpose of the Study:

    • To provide an updated overview of human enterovirus infections and associated diseases.
    • To highlight recent findings on novel enterovirus serotypes and their clinical impact.
    • To review established knowledge on older serotypes, including age-specific disease patterns and severe complications.

    Main Methods:

    • Literature review and synthesis of recent research on human enteroviruses.

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  • Analysis of epidemiological data on enterovirus serotypes and disease incidence.
  • Review of clinical case reports and pathological findings related to enterovirus infections.

    • Main Results:

    • Ongoing discovery of new enterovirus serotypes necessitates continuous surveillance and characterization.
    • Variations in age-specific attack rates for both new and old serotypes are observed.
    • Enteroviruses are linked to severe outcomes, including neurological complications (indicated by virus-positive cerebrospinal fluids) and prolonged infections in immunocompromised individuals (agammaglobulinemia).
    • Emerging evidence suggests enteroviruses play a role in the pathogenesis of myocardiopathies and insulin-dependent diabetes mellitus.

    Conclusions:

    • Human enteroviruses remain a significant public health concern due to emerging serotypes and diverse clinical presentations.
    • Further research is needed to fully elucidate the mechanisms underlying enterovirus-associated pathologies, particularly in the heart and pancreas.
    • Continued monitoring and characterization of enterovirus strains are essential for effective prevention and treatment strategies.