Some factors affecting glomerulopressin production by perfused rat liver

Studies were carried out on the production of the glucuronide hormone glomerulopressin by the isolated rat liver in male and female rats, and the effect on this production of an inhibitor (Novobiocin) and a stimulator (benzo-(a)pyrene) of glucuronyltransferase activity. It was observed that males produce more glomerulopressin than females, Novobiocin inhibits its production while benzo-(a)pyrene enhances it in females but not in males. The changes in glomerulopressin production are related to the changes in glucuronyltransferase activity observed by other authors, suggesting that this enzyme is involved in the production of glomerulopressin.