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The Influence of Liver Resection on Intrahepatic Tumor Growth
Published on: April 9, 2016
Expression of a cellular oncogene during liver regeneration
Science (New York, N.Y.)
|February 4, 1983
Summary
Cellular oncogene ras transcripts increase during rat liver regeneration following injury. This regulated increase in ras oncogene expression occurs with DNA synthesis activation and returns to normal levels within 72 hours.
Area of Science:
- Molecular biology
- Cellular biology
- Oncology
Background:
- Cellular oncogenes play a role in cell growth and development.
- Ras oncogenes are homologous to viral transforming genes.
- Liver regeneration involves complex cellular signaling pathways.
Purpose of the Study:
- To investigate the role of the cellular oncogene ras during liver regeneration.
- To determine if ras transcript levels change during non-neoplastic liver growth.
Main Methods:
- Partial hepatectomy and carbon tetrachloride injury were used to induce liver regeneration in rats.
- Quantification of ras transcripts in liver polysomal polyadenylated RNA.
Main Results:
- Ras transcript levels significantly increased during liver regeneration.
- The increase in ras transcripts coincided with the activation of DNA synthesis.
- Ras transcript levels returned to basal levels within 72 hours post-injury.
Conclusions:
- The cellular oncogene ras is transcriptionally regulated during liver regeneration.
- Ras oncogene expression is modulated in a controlled manner during non-neoplastic growth processes.
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