Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cochlear potentials in the Bronx waltzer mutant mouse.

G R Bock, G K Yates, M S Deol

    Neuroscience Letters
    |December 23, 1982
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Genetic deafness of central origin.

    Brain research·2013
    Same author

    In vivo evidence for a cochlear amplifier in the hair-cell bundle of lizards.

    Proceedings of the National Academy of Sciences of the United States of America·2001
    Same author

    Rate-intensity functions in the emu auditory nerve.

    The Journal of the Acoustical Society of America·2000
    Same author

    Changes to low-frequency components of the TEOAE following acoustic trauma to the base of the cochlea.

    Hearing research·1999
    Same author

    The role of intermodulation distortion in transient-evoked otoacoustic emissions.

    Hearing research·1999
    Same author

    Enhancement of electrically evoked oto-acoustic emissions associated with low-frequency stimulus bias of the basilar membrane towards scala vestibuli.

    The Journal of the Acoustical Society of America·1998
    Same journal

    Dynorphinergic neuroadaptations in the islands of Calleja: implications for alcohol use disorder.

    Neuroscience letters·2026
    Same journal

    Differential vulnerability of cochlear nuclei to Lmx1 deficiency: abnormal patterning and implications for auditory circuitry.

    Neuroscience letters·2026
    Same journal

    Role of nNOS/sGC pathway in the insular cortex in control of cardiovascular, autonomic and corticosterone responses to restraint stress in rats.

    Neuroscience letters·2026
    Same journal

    Jak1 inhibition reduces acute allodynia induced by specific upstream cytokines in rats: implications for the onset of Jak1 pain modulation.

    Neuroscience letters·2026
    Same journal

    Glucocorticoids-induced depressive-like behaviors in mice: oral ingestion of corticosterone or hydrocortisone - A comparative study.

    Neuroscience letters·2026
    Same journal

    Data-driven clustering of prefrontal activation identifies functional phenotypes under prioritized dual-task walking conditions in Parkinson's disease.

    Neuroscience letters·2026
    See all related articles

    The Bronx waltzer mouse model reveals absent inner hair cells, impacting cochlear nerve function. This study demonstrates outer hair cells

    Area of Science:

    • Oto-neurology
    • Auditory Neuroscience
    • Mammalian Cochlear Physiology

    Background:

    • The Bronx waltzer (B/W) mouse is a unique genetic model exhibiting specific cochlear defects.
    • Understanding hair cell function is crucial for diagnosing hearing loss and developing therapeutic strategies.

    Purpose of the Study:

    • To investigate the functional consequences of absent inner hair cells in the B/W mouse model.
    • To explore the electrophysiological properties of outer hair cells in the absence of inner hair cells.

    Main Methods:

    • Electrophysiological recordings were performed from the round window of B/W mutant mice.
    • Analysis of cochlear nerve action potentials and cochlear microphonics.
    • Assessment of positive and negative summating potentials.

    Related Experiment Videos

    Main Results:

    • B/W mice exhibit normal-appearing outer hair cells but absent inner hair cells.
    • Gross cochlear nerve action potentials are significantly reduced or absent.
    • Cochlear microphonics are present but diminished in amplitude.
    • Both positive and negative summating potentials were recorded.

    Conclusions:

    • The absence of inner hair cells in B/W mice leads to profound deficits in auditory nerve signaling.
    • Mammalian outer hair cells possess the intrinsic capability to generate both positive and negative direct current (DC) potentials.
    • This mouse model provides valuable insights into the distinct roles of inner and outer hair cells in auditory transduction.