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Amiodarone neuropathy.

A Martinez-Arizala, S M Sobol, G E McCarty

    Neurology
    |May 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Amiodarone, an anti-arrhythmic drug, can cause peripheral neuropathy in 10% of patients. This neurological side effect often improves when the amiodarone dosage is reduced or the drug is stopped.

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    Area of Science:

    • Cardiology
    • Neurology
    • Pharmacology

    Background:

    • Amiodarone is a widely used anti-arrhythmic medication for managing complex cardiac arrhythmias.
    • Peripheral neuropathy is a potential adverse effect associated with various medications.

    Purpose of the Study:

    • To investigate the incidence and characteristics of peripheral neuropathy in patients treated with amiodarone.
    • To assess the reversibility of amiodarone-induced peripheral neuropathy.

    Main Methods:

    • Observational study involving 50 patients treated with amiodarone for cardiac arrhythmias.
    • Clinical assessment and diagnosis of peripheral neuropathy based on established criteria.

    Main Results:

    • Peripheral neuropathy was identified in 5 out of 50 cases (10%) of patients receiving amiodarone.

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  • The observed neuropathy ranged in severity but demonstrated improvement upon dosage reduction or cessation of amiodarone therapy.

    • Conclusions:

    • Amiodarone is associated with a 10% risk of developing peripheral neuropathy.
    • Amiodarone-induced peripheral neuropathy is often manageable and reversible through dose adjustment or drug discontinuation.