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Thyroid function in a diabetic population.

N Bagchi

    Special Topics in Endocrinology and Metabolism
    |January 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

    Diabetes mellitus significantly impacts thyroid function, particularly in insulin-dependent cases, altering thyroid hormone levels and increasing risks of thyroid disorders. Further research is needed to confirm regulatory changes in humans.

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    Area of Science:

    • Endocrinology
    • Metabolic Disorders

    Background:

    • Diabetes mellitus is associated with various thyroid function alterations.
    • Insulin-dependent diabetes shows the most significant changes.

    Purpose of the Study:

    • To investigate the alterations in thyroid function in patients with diabetes mellitus.
    • To explore the impact of diabetes on thyroid hormone metabolism and regulation.

    Main Methods:

    • Analysis of plasma levels of thyroid hormones (T4, T3, rT3).
    • Assessment of thyroid autoantibodies.
    • Review of animal studies on hypothalamic-pituitary-thyroid axis regulation.

    Main Results:

    • Diminished plasma T3 and elevated rT3 observed in uncontrolled diabetes and diabetic ketoacidosis, linked to altered T4 monodeiodination.

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  • Increased prevalence of both hypothyroidism and hyperthyroidism in diabetic patients.
  • Higher incidence of thyroid autoantibodies in insulin-dependent diabetics.
  • Animal studies suggest impaired hypothalamic regulation and TSH response.

    • Conclusions:

    • Diabetes mellitus induces significant changes in thyroid hormone economy.
    • Altered deiodination pathways and potential regulatory disturbances are implicated.
    • The clinical relevance of these changes, including cellular hypothyroidism, requires further investigation in human subjects.