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A mouse gene on chromosome 5 that restricts infectivity of mink cell focus-forming recombinant murine leukemia

J W Hartley, R A Yetter, H C Morse

    The Journal of Experimental Medicine
    |July 1, 1983
    PubMed

    Insights

    A newly identified gene, Rmcf, restricts mink cell focus-forming (MCF) murine leukemia virus infection in mice. This dominant gene on chromosome 5 aids in studying MCF virus roles in leukemogenesis.

    Area of Science:

    • Virology
    • Genetics
    • Immunology

    Background:

    • Mink cell focus-forming (MCF) murine leukemia viruses are implicated in various leukemogenesis processes.
    • Specific mouse strains (DBA/1, DBA/2, CBA/N, CBA/Ca) exhibit resistance to MCF virus infection.

    Purpose of the Study:

    • To identify and characterize the genetic basis of resistance to MCF virus infection in specific mouse strains.
    • To investigate the inheritance pattern and chromosomal location of the resistance gene.

    Main Methods:

    • Cross-breeding experiments with resistant and susceptible mouse strains.
    • Genetic linkage analysis to map the resistance gene.
    • Phenotypic characterization of viral infectivity.

    Main Results:

    • A dominant or semidominant gene, designated Rmcf, was identified as responsible for restricting MCF virus infectivity.
    • The Rmcf gene is located on chromosome 5 and is closely linked to the Hm gene.
    • The Rmcf gene effectively restricts MCF virus infection in DBA/1, DBA/2, CBA/N, and CBA/Ca mice.

    Conclusions:

    • The Rmcf gene provides a valuable tool for studying the pathogenesis of MCF virus-induced leukemias.
    • Understanding the Rmcf gene's function can contribute to developing strategies for controlling retroviral infections and leukemogenesis.

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