Lincomycin dose response for treatment of necrotic enteritis in broilers

Area of Science:

• Veterinary Medicine
• Animal Science
• Poultry Health

Background:

• Necrotic enteritis (NE) poses a significant threat to broiler health and productivity.
• Effective treatment strategies are essential for managing NE outbreaks in commercial poultry operations.

Purpose of the Study:

• To determine the optimal lincomycin concentration in drinking water for treating NE in broilers.
• To establish the minimal effective dose for maximal therapeutic response.

Main Methods:

• A dose-response study involving 2,895 broilers over two replicates.
• Lincomycin administered via drinking water at concentrations ranging from 0 to 33.818 mg/liter for 7 days.
• Mortality and pathological findings used for NE diagnosis; statistical analysis via ANOVA and Walker-Carmer technique.

Main Results:

• Lincomycin demonstrated efficacy in treating NE at concentrations ≥ 2.114 mg/liter.
• The estimated optimal dose for maximal treatment response against NE was 16.9 mg lincomycin/liter of drinking water.

Conclusions:

• Lincomycin is an effective treatment for necrotic enteritis in broilers.
• The optimal dosage for maximizing treatment efficacy against NE in broilers is 16.9 mg/liter in drinking water.