Related Experiment Video
Updated: Aug 12, 2026

Combined Immunofluorescence and DNA FISH on 3D-preserved Interphase Nuclei to Study Changes in 3D Nuclear Organization
Published on: February 3, 2013
Transcriptional enhancer elements in the mouse immunoglobulin heavy chain locus
Abstract:
Two regions in the immunoglobulin heavy chain locus were tested for their ability to enhance transcription of the SV40 early promoter. A portion of the intervening sequence between the heavy chain joining region (Jh) and the constant region of the mu chain (Cmu) can enhance transcription when it is cloned either 5' or 3' to the SV40 early promoter. The region between C alpha and the alpha switch site, which occurs 5' to the translocated c-myc oncogene in many murine plasmacytomas, does not show transcriptional enhancer activity in this assay.
Related Concept Videos
Transcription Factors
RNA Polymerase II Accessory Proteins
Master Transcription Regulators
General Transcription Factors
RNA Polymerase II Accessory Proteins
Master Transcription Regulators

