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Association of herpes simplex virus with platelets of experimentally infected mice
Archives of Virology
|January 1, 1983
Abstract:
In mice infected with herpes simplex virus (HSV) type 1 by the intracerebral route or with HSV type 2 by the vaginal route, virus was shown to be present in greater quantities in purified platelets than in leucocytes or other blood components. Results of the studies described suggest that platelets may play a major role in the hematogenous dissemination of HSV infection.
Insights
Platelets carry more herpes simplex virus (HSV) than white blood cells in infected mice. This suggests platelets are key to spreading HSV through the bloodstream.
Area of Science:
- Virology
- Hematology
Background:
- Herpes simplex virus (HSV) can cause serious infections.
- The mechanisms of HSV dissemination in the body are not fully understood.
Purpose of the Study:
- To investigate the role of blood components in the hematogenous spread of HSV.
Main Methods:
- Mice were infected with HSV type 1 intracerebrally or HSV type 2 vaginally.
- Virus quantities in purified platelets, leucocytes, and other blood components were measured.
Main Results:
- HSV was found in significantly greater quantities in purified platelets compared to leucocytes and other blood components.
- This was observed in both HSV-1 and HSV-2 infection models.
Conclusions:
- Platelets may play a significant role in the bloodstream dissemination of HSV infections.
- Further research into platelet-mediated viral transport is warranted.