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[Acute hepatitis caused by isaxonine phosphate (Nerfactor)].

F Baud, J Bernuau, N Benmami

    Gastroenterologie Clinique Et Biologique
    |April 1, 1983
    PubMed
    Summary

    Isaxonine phosphate (Nerfactor) can cause acute hepatitis in adults, leading to liver damage and, in severe cases, fatalities. This drug-induced liver injury may involve an immuno-allergic reaction.

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    Area of Science:

    • Hepatology
    • Toxicology
    • Immunology

    Background:

    • Isaxonine phosphate (Nerfactor) is a novel therapeutic agent investigated for treating peripheral nerve lesions.
    • The safety profile of isaxonine phosphate, particularly concerning liver function, requires thorough evaluation.

    Observation:

    • Four adult patients developed acute hepatitis following administration of isaxonine phosphate.
    • Hepatitis onset ranged from 14 to 166 days after initiating the drug.
    • Liver biopsy revealed predominantly centrilobular hepatocytic necrosis in all affected patients.

    Findings:

    • Isaxonine phosphate is associated with drug-induced liver injury (DILI).
    • The clinical presentation included acute hepatitis with significant hepatocyte necrosis.

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  • Two cases resulted in fatal outcomes, highlighting the potential severity of this adverse reaction.

    • Implications:

    • Hepatotoxicity should be considered a potential risk associated with isaxonine phosphate therapy.
    • The immuno-allergic mechanism warrants further investigation to understand the pathogenesis of isaxonine phosphate-induced hepatitis.
    • Clinical monitoring for liver function is crucial in patients receiving isaxonine phosphate.