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Related Experiment Videos

Theophylline disposition in obesity.

P Gal, W J Jusko, A M Yurchak

    Clinical Pharmacology and Therapeutics
    |April 1, 1978
    PubMed
    Summary

    Theophylline dosing in obese patients differs from normal subjects. Loading doses should use total body weight, while maintenance doses should use ideal body weight for accurate theophylline therapy.

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    Area of Science:

    • Pharmacokinetics
    • Obesity Medicine

    Background:

    • Theophylline is a common medication for respiratory diseases.
    • Understanding its disposition in obese individuals is crucial for safe and effective dosing.

    Purpose of the Study:

    • To investigate theophylline disposition in obese versus normal-weight subjects.
    • To determine appropriate weight parameters for calculating theophylline loading and maintenance doses.

    Main Methods:

    • Administered oral aminophylline to 14 obese and 57 normal subjects.
    • Collected serum and saliva samples over several hours.
    • Analyzed samples using high-pressure liquid chromatography to determine theophylline levels.

    Main Results:

    • Volume of distribution (Vd) normalized by total body weight (TBW) was similar between groups, suggesting TBW for loading doses.
    • Body clearance (ClB) normalized by ideal body weight (IBW) was similar, indicating IBW for maintenance doses.
    • Mean half-life was longer in obese subjects, implying potentially less frequent dosing is needed.

    Conclusions:

    • Theophylline loading doses should be based on total body weight.
    • Theophylline maintenance doses should be based on ideal body weight.
    • Obese patients may require less frequent theophylline dosing due to longer half-lives.

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