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Tympanostomy tubes and otic drops.

W L Meyerhoff, T Morizono, C G Wright

    The Laryngoscope
    |August 1, 1983
    PubMed
    Summary
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    Topical otic drops, like Cortisporin, may cause hearing loss in patients with tympanostomy tubes. Studies show these drops can damage cochlear hair cells and affect auditory nerve function, necessitating cautious use.

    Area of Science:

    • Otolaryngology
    • Audiology
    • Pharmacology

    Background:

    • Otic drops are used for prophylaxis against otitis media in patients with tympanostomy tubes.
    • Potential adverse effects of otic drops on hearing require investigation.

    Purpose of the Study:

    • To evaluate the ototoxicity of Cortisporin otic suspension in chinchillas with tympanostomy tubes.
    • To assess the impact of topical otic agents on cochlear and VIIIth nerve function.

    Main Methods:

    • Chinchillas with tympanostomy tubes received Cortisporin otic suspension.
    • Auditory function was measured using VIIIth nerve action potentials.
    • Cochlear hair cells were examined via histological and scanning electron microscopy.

    Main Results:

    Related Experiment Videos

    • Cortisporin otic drops reached the middle ear in animals with patent eustachian tubes.
    • Significant hearing attenuation was observed in ears treated with Cortisporin.
    • Hair cell loss in the cochlear hook region was identified in treated ears.

    Conclusions:

    • Topical otic agents, including Cortisporin, may be ototoxic in patients with tympanostomy tubes.
    • Caution is advised when using potentially ototoxic topical agents in this patient population.
    • Further research is needed to understand the long-term effects and safe usage guidelines.