Changes in electrical potential difference and sodium-potassium ATPase of canine mucosa after jejunal-ileal bypass...

Changes in electrical potential difference and sodium-potassium ATPase activity of rectal mucosa in dogs were examined before and after jejunal-ileal bypass surgery. The potential difference in the postoperative period was significantly higher (P less than 0.05) than the preoperative value. The potential difference increased by 160% at the 3rd day after the surgery, and then gradually declined with prolonged recovery periods. Ouabain-sensitive sodium-potassium ATPase activity also increased at the 3rd day (160%) and at the 10th day (86%) after the surgery. Fourteen days after the surgery the sodium-potassium ATPase activity returned almost to the preoperative value. These results indicated a close correlation between changes in transmucosal potential difference and sodium-potassium ATPase activity of rectal mucosa, suggesting a significant participation of sodium-potassium ATPase in changes of potential difference induced by jejunal-ileal bypass surgery.