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Some biochemical platelet patterns in stable coronary patients
Pharmacological Research Communications
|May 1, 1983
Insights
Patients with stable angina pectoris showed altered platelets, with decreased platelet aggregate ratio and increased malondialdehyde production. However, platelet cyclic AMP levels remained stable, even after thrombin stimulation.
Area of Science:
- Biochemistry
- Hematology
- Cardiology
Background:
- Stable angina pectoris is associated with platelet dysfunction.
- Platelet ultrastructure alterations are observed in affected patients.
Purpose of the Study:
- To investigate biochemical changes in platelets of patients with stable angina pectoris.
- To correlate ultrastructural platelet alterations with biochemical parameters.
Main Methods:
- Platelet function tests were performed.
- Biochemical assays were used to measure malondialdehyde (MDA) production and cyclic AMP (cAMP) content.
- Platelet aggregate ratio (PAR) was assessed.
Main Results:
- A decrease in platelet aggregate ratio (PAR) was observed.
- Malondialdehyde (MDA) production was increased under specific conditions.
- Platelet cyclic AMP (cAMP) content remained stable, even following thrombin stimulation.
Conclusions:
- Platelet biochemical alterations, including decreased PAR and increased MDA, are present in stable angina.
- The stability of cAMP suggests a specific platelet response mechanism in this condition.
Abstract:
Patients affected by stable angina pectoris whose platelets were characterized by ultrastructural alterations, were investigated in some biochemical changes of their platelets. A decrease of P.A.R. (platelet aggregate ratio), an increase of MDA production in particular conditions, nevertheless a stability of cAMP content in platelets, even after thrombin stimulation, were found.