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Related Experiment Videos

Breast neoplasms containing bone and cartilage.

D V Spagnolo, K B Shilkin

    Virchows Archiv. A, Pathological Anatomy and Histopathology
    |January 1, 1983
    PubMed
    Summary

    Bone and cartilage are rarely found in human breast neoplasms. This study reviewed 307 breast lesions, confirming the infrequent occurrence of these tissues in fibroadenomas and breast carcinomas.

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    Area of Science:

    • Pathology
    • Oncology
    • Surgical Pathology

    Background:

    • Bone and cartilage formation (osseous and chondroid metaplasia) in breast neoplasms is an uncommon phenomenon.
    • Previous literature suggests rarity, but comprehensive frequency data is limited.

    Purpose of the Study:

    • To determine the frequency of bone and/or cartilage in a series of breast neoplasms and tumour-like conditions.
    • To review and discuss these rare osseous and chondroid lesions in the breast.

    Main Methods:

    • Retrospective review of 307 breast neoplasms and tumour-like conditions.
    • Histopathological analysis to identify the presence of bone and/or cartilage.

    Main Results:

    • Osseous metaplasia was identified in 1 of 90 fibroadenomas (1.1%) and 2 of 158 breast carcinomas (1.3%).
    • Cartilage was found in one benign mesenchymoma, and both bone and cartilage were present in one benign mixed tumour (pleomorphic adenoma).
    • No bone or cartilage was observed in 22 papillomas or 34 cases of gynaecomastia.

    Conclusions:

    • The occurrence of bone and/or cartilage in human breast neoplasms is confirmed to be rare.
    • These metaplastic changes are infrequent findings in common breast lesions like fibroadenomas and carcinomas.

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