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Estimation of the single stranded region in the nuclear DNA of mouse tissues during aging with special reference to
Archives of Gerontology and Geriatrics
|September 1, 1982
Abstract:
The proportion of single stranded DNA in various tissues of mouse during aging was examined by measuring sensitivity to a single-strand specific nuclease. Brain DNA from mice of more than 15 mth old contained 3% of the single stranded regions while that from younger animals contained 2%. The DNAs from liver, kidney, heart and spleen did not show significant age-associated changes.