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Updated: Aug 24, 2026

Determining Immune System Suppression versus CNS Protection for Pharmacological Interventions in Autoimmune Demyelination
Published on: September 12, 2016
"Bolus" methylprednisolone versus ACTH in the treatment of multiple sclerosis
Abstract:
Two groups of 30 multiple sclerosis (MS) patients were randomly treated with corticotrophin (ACTH) and "bolus" 6-methylprednisolone (B/6-MP) to compare the effectiveness of the two treatments. Both ACTH and B/6-MP showed a similar effect, improving acute neurological deficits of MS patients without modifying the long term course of the disease. B/6-MP, showing prompt effectiveness and lack of side effects, may be regarded as a useful alternative to conventional treatment of MS.
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