Cardiac arrhythmias after intravenous administration of glucagon

The effect of glucagon on the circulatory system was studied in 22 healthy men. The drug was administered in doses of 50 microgram/kg of body weight for 30 sec. In the case of 5 subjects, arrhythmias occurred that manifested themselves as ventricular and supraventricular extrasystoles. In the case of 1 subject, who had sporadic ventricular fusion beats in the preexamination period, the arrhythmia increased following glucagon injection.