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Anaphylaxis-induced increase in plasma cyclic AMP dependent on endogenous catecholamines in rats
Pharmacology
|January 1, 1983
Summary
Anaphylactic shock in rats significantly increases plasma cyclic AMP. The adrenal medulla is the primary source, with some contribution from neuronal catecholamines, influencing this response.
Area of Science:
- Immunology
- Pharmacology
- Physiology
Background:
- Anaphylactic shock is a severe allergic reaction.
- Cyclic adenosine monophosphate (cAMP) plays a role in cellular signaling during anaphylaxis.
Purpose of the Study:
- To investigate the source of plasma cyclic AMP elevation during anaphylactic shock in rats.
- To determine the role of catecholamines and the adrenal medulla in this response.
Main Methods:
- Ovalbumin-sensitized rats were subjected to anaphylactic shock.
- Plasma cyclic AMP levels were measured in control and experimental groups.
- Groups included adrenomedullectomized, propranolol-treated, reserpinized, chemically sympathectomized, hexamethonium-treated, and cocaine-treated rats.
Main Results:
- Plasma cyclic AMP increased rapidly during anaphylactic shock in control rats.
- Adrenomedullectomy abolished the increase, while propranolol dose-dependently inhibited it.
- Reserpine, 6-hydroxydopamine, and cocaine partially inhibited the cyclic AMP increase.
Conclusions:
- The adrenal medulla is the main source of catecholamines during rat anaphylactic shock.
- Catecholamines from adrenergic neuronal terminals contribute partly to the plasma cyclic AMP elevation during anaphylaxis.