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Human ovaries contain immunoreactive oxytocin.
The Journal of Clinical Endocrinology and Metabolism
|December 1, 1983
Summary
This study found oxytocin (OT) in human ovaries, particularly in the corpus luteum and preovulatory follicles. These ovarian tissues may produce OT, potentially acting as a luteolytic agent.
Area of Science:
- Reproductive Endocrinology
- Hormone Research
- Gynecology
Background:
- Oxytocin (OT) is a well-known hormone primarily associated with childbirth and lactation.
- Its presence and function within the human ovary have not been extensively studied.
Purpose of the Study:
- To investigate the presence and concentration of oxytocin (OT) in various human ovarian tissues.
- To explore the potential role of ovarian oxytocin in reproductive processes.
Main Methods:
- Ovarian tissues (n=26) were collected during surgery.
- Radioimmunoassay (RIA) was used to quantify immunoreactive oxytocin (OT) concentrations.
- Sephadex G-25 column chromatography confirmed the identity of the measured substance.
Main Results:
- Significant concentrations of immunoreactive OT were detected in the corpus luteum and preovulatory follicles.
- Ovarian stromal tissue showed lower or undetectable OT levels.
- OT was not detected in a luteoma, cystadenoma, or endometriotic cyst, but was present in a thecoma and polycystic ovaries.
Conclusions:
- Immunoreactive oxytocin is present in human ovaries, with notable levels in the corpus luteum and preovulatory follicles.
- These ovarian tissues likely produce oxytocin or an oxytocin-like substance.
- Ovarian oxytocin may function as a luteolytic agent, playing a role in regulating the corpus luteum.