Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Multiple exercise-related mononeuropathy with abdominal colic.

U Trockel, J M Schröder, K H Reiners

Journal of the Neurological Sciences

|August 1, 1983

Summary

Hereditary neuropathy with liability to pressure palsies (NLPP) presents with recurrent nerve damage from minor pressure. This variant causes painful palsies and abdominal colic, possibly due to a metabolic factor affecting myelin and autonomic nerves.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Deep Brain Stimulation of the Nucleus Basalis of Meynert in Alzheimer's Dementia: Potential Predictors of Cognitive Change and Results of a Long-Term Follow-Up in Eight Patients.

Brain stimulation·2016

Same author

Enhanced regional cerebral metabolic interactions in thalamic circuitry predicts motor recovery in hemiparetic stroke.

Human brain mapping·2010

Same author

Identification of mutations in the uroporphyrinogen III cosynthase gene in German patients with congenital erythropoietic porphyria.

Physiological research·2007

Same author

Fischer-Tropsch synthesis on anchored Co/Nb2O5/Al2O3 catalysts: the nature of the surface and the effect on chain growth.

The journal of physical chemistry. B·2006

Same author

Cluster core-level binding-energy shifts: the role of lattice strain.

Physical review letters·2004

Same author

Representational cortical plasticity associated with brain tumours: evidence from laser-induced interstitial thermotherapy.

Acta neurologica Scandinavica·2003

Area of Science:

Neurology
Genetics
Pathology

Background:

Hereditary neuropathy with liability to pressure palsies (NLPP) is a rare genetic disorder.
It causes recurrent sensory-motor deficits triggered by minor pressure.
This report details a unique variant observed in siblings.

Observation:

Siblings experienced painful palsies after strenuous activity and abdominal colic.
Symptoms mimicked acute intermittent porphyria.
Electrophysiological studies revealed typical NLPP nerve conduction abnormalities.

Findings:

Microscopic examination showed characteristic NLPP lesions, including myelin sheath swelling.
Frequent observation of non-compacted, "loose" myelin lamellae and distended Schmidt-Lantermann incisures.

Related Experiment Videos

Non-compacted myelin was a significant feature of this demyelinating neuropathy.

Implications:

Suggests an unknown metabolic factor contributes to this NLPP variant.
This factor may cause peripheral nerve demyelination and autonomic nerve dysfunction.
The metabolic factor could explain both the nerve palsies and abdominal pain episodes.