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Opioid peptides with differential affinity for mu and delta receptors decrease sensory neuron calcium-dependent

M A Werz, R L Macdonald

    The Journal of Pharmacology and Experimental Therapeutics
    |November 1, 1983
    PubMed
    Summary
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    This study reveals that both mu and delta opiate receptors are involved in reducing calcium action potentials in dorsal root ganglion neurons. Opioid peptide effects varied, indicating a mixed receptor involvement.

    Area of Science:

    • Neuroscience
    • Pharmacology

    Background:

    • Opioid peptides are known to decrease calcium action potentials via opiate receptors.
    • The specific roles of mu and delta opiate receptors in this process require further clarification.

    Purpose of the Study:

    • To investigate the differential involvement of mu and delta opiate receptors in modulating calcium-dependent action potentials of dorsal root ganglion (DRG) neurons.
    • To compare the potency of Leu-enkephalin and morphiceptin, which have distinct affinities for mu and delta receptors, on DRG neurons.
    • To assess agonist sensitivity to naloxone antagonism, considering naloxone's varying affinities for mu and delta receptors.

    Main Methods:

    • Tested the effects of Leu-enkephalin and morphiceptin on DRG neuron somatic calcium-dependent action potentials.
    • Administered equimolar concentrations of opioid peptides to individual DRG neurons.

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  • Investigated agonist sensitivity to naloxone antagonism in neurons exhibiting differential responses.

    • Main Results:

    • Observed heterogeneous responses to Leu-enkephalin and morphiceptin, with some neurons responding equally, others only to Leu-enkephalin.
    • Identified varying sensitivities to naloxone antagonism based on the observed response patterns to the opioid peptides.
    • Neurons responding only to Leu-enkephalin showed significantly lower sensitivity to naloxone compared to those responding to both.

    Conclusions:

    • Both mu and delta opiate receptors mediate decreases in somatic calcium-dependent action potentials of DRG neurons.
    • The findings suggest a complex interplay between mu and delta opiate receptor subtypes in regulating neuronal excitability.